Before preparing your content, consider your audience. Who are they? What matters to them? What do they know about your topic? What do they want to know?
Once you have evaluated your audience, ask yourself why you are giving your presentation and what you are trying to achieve. You may want to motivate, persuade, educate, and/or entertain. Know your objectives.
If you want an audience to care about your content, you have to care about it yourself. Therefore, you need to understand and personally connect to your topic. Find the elements of your talk that matter to you most, and use them to strengthen your connection to the presentation. If you can demonstrate sincere interest and belief in your topic, your enthusiasm will spread to the audience.
Your presentation will be most powerful at the intersection of what you care about and what matters to your listeners.